| Title | Bacterial resistance to antibiotics in acne vulgaris: an in vitro study. | | Author(s) | Hassanzadeh P, Bahmani M, Mehrabani D | | Source | Indian J Dermatol 2008; 53(3):122-4. | | Abstract | BACKGROUND: Acne vulgaris is one of the most common skin disorders in youth especially during the puberty.
OBJECTIVE: This in vitro study was performed to determine the antibiotic resistance and sensitivity in acne vulgaris.
MATERIALS AND METHODS: Samples were collected from normal skin and nodulocystic and pustular skin lesions of one hundred youngsters (64 girls, 36 boys) among college students in the age range of 18-24 years old. The specimens were cultured individually on blood agar and Muller-Hinton media. The cultures were then incubated under both aerobic and anaerobic conditions for 2 to 7 days. Bacteria were identified and their resistance to common antibiotics was evaluated according to the standard procedures.
RESULTS: In aerobic culture of pustular and nodulocystic skin lesions, Staphylococcus aureus was present in 41% of subjects, Staphylococcus epidermidis in 53% and Micrococcus spp in 45% of subjucts. In anaerobic bacterial culture of pustular and nodulocystic skin lesions, Staphylococcus aureus was present in 39%, Propionibacterium acne in 33% and Staphylococcus epidermidis in 21% of subjects. The results of present study revealed that clindamycin and erythromycin were the least effective antibiotics for Propionibacterium acne while tetracycline was the least effective for Staphylococcus aureus in vitro. A synergic effect of benzoyl peroxide, erythromycin or clindamycin was noticed. Rifampin was the most effective antibiotic in vitro.
CONCLUSION: Our results showed that rifampin was the most sensitive antibiotic in vitro for acne vulgaris. To achieve a better treatment, a combination of rifampin with other antibiotics may be more efficient. We suggest in vivo studies for better evaluation and treatment of acne patients with rifampin. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19882009 |
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