| Title | Warfarin anticoagulation reversal: management of the asymptomatic and bleeding patient. | | Author(s) | Makris M, van Veen JJ, Maclean R | | Institution | Sheffield Haemophilia and Thrombosis Centre, University of Sheffield, Sheffield, UK, m.makris@sheffield.ac.uk. | | Source | J Thromb Thrombolysis 2009 Nov 1. | | Abstract | The management of patients with supra-therapeutic INR in a common clinical problem. The risk of bleeding is influenced by the intensity, variability and duration of anticoagulation, patient age, presence of co-morbidities and concomitant drug therapy. For the asymptomatic patient, warfarin discontinuation is all that is usually required but for individuals at high risk of bleeding and those with INR > 10, oral vitamin K administration is recommended. In the presence of major bleeding, treatment with intravenous vitamin K and prothrombin complex concentrate is the most effective therapy. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19882303 |
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