| Title | Primary low-risk trabeculectomy augmented with low-dose mitomycin-C. | | Author(s) | Alwitry A, Abedin A, Patel V, Moodie J, Rotchford A, King AJ | | Institution | Eye, Ear, Nose and Throat Centre, Queens Medical Centre, Nottingham - UK. | | Source | Eur J Ophthalmol 2009 Jul 6. | | Abstract | Purpose. To present outcome data on low risk primary trabeculectomy augmented with low dose peroperative (0.1 mg/mL for 1 minute) mitomycin-C (MMC). Methods. Retrospective case note review. All cases of trabeculectomy utilizing MMC augmentation at a concentration of 0.1 mg/mL with an application time of 1 minute and at least 1 year follow-up during the study period were included. Only first eyes were included. Patient demographics and postoperative course including complications, interventions, and outcomes were documented and analyzed.
Results. Fifty-nine trabeculectomies that met the inclusion criteria were identified. Mean age of cases was 70.8 years. Mean follow-up time was 19.3 months. Bleb leaks occurred in 16 (27.1%) cases. Only one case required surgical intervention in the form of resuturing after 14 days. At 1 year, there was a reduction in mean number of topical medications from 2.70 to a mean of 0.07. Unqualified success (intraocular pressure [IOP] at 1 year of less than 16 mmHg without medication) was achieved in 49 cases (83.1%). Mean IOP was reduced from the preoperative value of 23.1 mmHg (SD 5.8) to 13.5 mmHg (SD 5.0) (p<0.001).
Conclusions. Our data suggest that a primary trabeculectomy augmented with a low dose of MMC is a safe and effective procedure for IOP reduction in patients with a low risk of trabeculectomy failure. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19882580 |
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