| Title | Reduced Digestive Vacuolar Accumulation of Chloroquine is Not Linked to Resistance to Chloroquine Toxicity. | | Author(s) | Cabrera M, Paguio MF, Xie C, Roepe PD | | Source | Biochemistry 2009 Nov 2. | | Abstract | Chloroquine (CQ) accumulation studies in live malaria parasites are typically done at low nM [CQ], and definition of CQ resistance (CQR) has been via growth inhibition assays vs low dose CQ (i.e. via IC50 ratios). These data have led to the near universally accepted idea that reduced parasite CQ accumulation is the underlying basis of CQR. Surprisingly, when quantifying CQR via cytocidal CQ activity and examining CQ accumulation at medically relevant LD50 doses, we find reduced CQ accumulation is not the underlying cause of CQR. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19883122 |
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