| Title | Fabrication and evaluation of captopril modified-release oral formulation. | | Author(s) | Gohel M, Nagori SA | | Institution | Department of Pharmaceutics, L. M. College of Pharmacy, Opp Gujarat University, Navrangpura, Ahmedabad, 380 009 India. | | Source | Pharm Dev Technol 2009 Dec; 14(6):679-686. | | Abstract | The present research was directed towards fabrication of modified-release captopril oral formulation. A 3(2) full factorial design was employed for optimization using captopril to Compritol(R) ATO 888 ratio (X(1)) and extragranular fraction of ethyl cellulose (X(2)) as independent variables. The percentage drug released in 1 h (Y(1)) and the time required to release 80% of the drug (Y(2)) were selected as dependent variables. Eutectic blend of camphor and menthol was used as a solvent to facilitate the drug distribution in matrix. The optimized batch containing 50 mg captopril, 160 mg Compritol(R) ATO 888 and 220 mg ethyl cellulose was formulated by overlapping the contour plots of Y(1) and Y(2). The responses Y(1) and Y(2) of optimized batch were 25% and 520 min, respectively. The kinetics of drug release was best explained by Korsmeyer-Peppas model. The results of artificial neural network were superior in prediction power than the factorial design for both the responses (Y(1) and Y(2)). | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19883258 |
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