Unbound MEDLINE

1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT(6) receptor ligands. Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] Journal article

 
Bernotas RC, Antane SA, Lenicek SE, Haydar SN, Robichaud AJ, Harrison BL, Zhang GM, Smith D, Coupet J, Schechter LE 
1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT(6) receptor ligands. [JOURNAL ARTICLE]
Bioorg Med Chem Lett 2009 Oct 20.


1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines were prepared. Binding assays indicated they are 5-HT(6) receptor ligands, among which 6f and 6g showed high affinity for 5-HT(6) receptors with K(i)=3.9 and 1.7nM, respectively.


More from this journal
  
Advertise on this site.