| Title | 1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT(6) receptor ligands. | | Author(s) | Bernotas RC, Antane SA, Lenicek SE, Haydar SN, Robichaud AJ, Harrison BL, Zhang GM, Smith D, Coupet J, Schechter LE | | Institution | Chemical Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. | | Source | Bioorg Med Chem Lett 2009 Oct 20. | | Abstract | 1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines were prepared. Binding assays indicated they are 5-HT(6) receptor ligands, among which 6f and 6g showed high affinity for 5-HT(6) receptors with K(i)=3.9 and 1.7nM, respectively. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19884004 |
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