| Title | Lab-on-a-Chip With ¿-Poly(Vinylidene Fluoride) Based Acoustic Microagitation. | | Author(s) | Cardoso V, Catarino S, Nunes J, Rebouta L, Lanceros-Mendez S, Minas G | | Source | IEEE Trans Biomed Eng 2009 Oct 30. | | Abstract | This paper reports a fully-integrated disposable lab-on-a-chip with acoustic microagitation based on a piezoelectric -Poly(vinylidene fluoride), -PVDF, polymer. The device can be used for the measurement, by optical absorption spectroscopy, of biochemical parameters in physiological fluids. It comprises two dies: the fluidic die that contains the reaction chambers fabricated in SU-8 and the -PVDF polymer deposited underneath them; and the detection die that contains the photodetectors, its readout electronics and the piezoelectric actuation electronics, all fabricated in a CMOS microelectronic process. The microagitation technique improves mixing and shortens reaction time. Further, it generates heating, which also improves the reaction time of the fluids. In the present work, the efficiency of the microagitation system is evaluated as a function of the amplitude and the frequency of the signal actuation. The relative contribution of the generated heating is also discussed. The system is tested for the measurement of the uric acid concentration in urine. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19884076 |
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