Watanabe D, Kuhara T, Ishida N, Takama H, Tamada Y, Matsumoto Y
Herpes zoster of the nipple: rapid DNA-based diagnosis by the loop-mediated isothermal amplification method. [JOURNAL ARTICLE]
Int J STD AIDS 2009 Nov 2.
A 28-year-old Japanese man presented with grouped erosions and vesicles on an erythematous base affecting the right areola and the surrounding skin. Tzanck test from the vesicle revealed giant cells. Clinical diagnosis of mammary herpes simplex was first considered. For differential diagnosis, viral DNA was amplified by the loop-mediated isothermal amplification (LAMP) method. DNA replication was observed only in varicella zoster virus LAMP mixture, and then confirmed diagnosis of herpes zoster was made. The patient was treated with 3000 mg of daily valacyclovir for seven days. After antiviral treatment, the lesion was healed and the pain was completely disappeared.
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