Verification of the Newly Proposed T Category (Seventh Edition of the Tumor, Node, and Metastasis Classification) from a Clinicopathological Viewpoint in Non-small Cell Lung Cancer-Special Reference to Tumor Size. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] Journal article | | Title | Verification of the Newly Proposed T Category (Seventh Edition of the Tumor, Node, and Metastasis Classification) from a Clinicopathological Viewpoint in Non-small Cell Lung Cancer-Special Reference to Tumor Size. | | Author(s) | Yano T, Morodomi Y, Ito K, Yoshida T, Haro A, Shoji F, Koga T, Maehara Y | | Institution | Departments of *Surgery and Science, and daggerPathophysiological and Experimental Pathology, Graduate School of Medical Sciences, Kyushu University Fukuoka, Japan. | | Source | J Thorac Oncol 2009 Oct 30. | | Abstract | INTRODUCTION:: This study first verified the T classification, which is the major point of the revision regarding the seventh Tumor, Node, and Metastasis classification, from a viewpoint of the clinicopathological findings at the primary tumor site in non-small cell lung cancer.
METHODS:: The medical records of 1393 patients with non-small cell lung cancer who underwent a complete resection at this hospital from 1974 to 2003 were thoroughly reviewed for pathologic findings and survival.
RESULTS:: According to greatest dimension of the primary tumors, the 5-year postoperative survival was 77.8% for T1a (</=2 cm), 63.3% for T1b (</=3 cm), 46.4% for T2a (</=5 cm), 38.8% for T2b (<7 cm), and 21.4% for T3 (>7 cm). The differences among those new T categories were all statistically significant. The incidence of lymphatic permeation within the primary tumor was 17.2% for T1b and 29.8% for T2a (T1b versus T2a, p < 0.05). The incidence of vascular invasion within the primary tumor was 24.9% for T1b, 35.3% for T2a, and 54.2% for T2b (T1b versus T2a and T2a versus T2b, p < 0.05). On the other hand, the incidence of pleural invasion of the primary tumor was 18.1% for T1a, 29.4% for T1b, 49.3% for T2a, 47.3% for T2b, and 87.5% for T3 (T1a versus T1b, T1b versus T2a, T2b versus T3, p < 0.05). Significant differences were observed among the newly revised T subsets in at least one incidence of lymphatic, vascular, or pleural invasion.
CONCLUSION:: The new T classification, which is based mainly on the tumor size, is therefore considered to be appropriate for the pathologic findings of the primary tumor. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19884855 |
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