| Title | Immunosuppressive therapy for autoimmune inner ear disease. | | Author(s) | Buniel MC, Geelan-Hansen K, Weber PC, Tuohy VK | | Institution | Cleveland Clinic, Lerner Research Institute, Department of Immunology, NB30, 9500 Euclid Avenue, Cleveland, OH 44195, USA, Tel.: +1 216 445 9684, , tuohyv@ccf.org. | | Source | Immunotherapy 2009; 1(3):425-434. | | Abstract | Autoimmune inner ear disease (AIED) is a rare disease that is diagnosed after clinical suspicion and response to corticosteroids. AIED manifests as progressive, bilateral, although often asynchronous, sensorineural hearing loss and can be associated with vestibular symptoms. Since its description as a defined disease entity in 1979, the initial mainstay of treatment remains high-dose corticosteroids. Several animal models have been developed to assist in determining efficacy of immunosuppression in AIED, and several clinical studies have also investigated the role of both steroid and steroid-sparing treatments. Here we discuss the basic science and clinical research surrounding the history of immunosuppressive therapy in AIED. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19885385 |
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