Dole VS, Smola H, Dooley S, Said HM, Oldak M, Pfister HJ, Smola S
The adenoviral E1A oncoprotein activates the Smad7 promoter: Requirement of a functional E-box. [JOURNAL ARTICLE]
Int J Oncol 2009 Dec; 35(6):1493-1498.
DNA tumorviruses like adenoviruses (AdV) or human papillomaviruses (HPV) have adopted various strategies to interfere with antiproliferative transforming growth factor-beta (TGF-beta) signalling. Here we report that the AdV E1A oncoprotein is sufficient to induce Smad7 expression, an inhibitor of TGF-beta signalling. E1A but not HPV oncoproteins activated the Smad7 promoter. A promoter proximal E-box was crucial for E1A-mediated transcriptional activity. E1A but not HPV oncoproteins induced specific binding activity at this E-box, which was identified as upstream stimulatory factor. In conclusion, these results unravel a novel mechanism of how the AdV E1A oncoprotein induces a cellular inhibitor of TGF-beta signalling.
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