| Title | Suppression of non-sustained ventricular tachycardia with ranolazine: a case report. | | Author(s) | Kaliebe JW, Murdock DK | | Institution | CaRE Foundation, Inc, Wausau, WI 54401, USA. | | Source | WMJ 2009 Oct; 108(7):373-5. | | Abstract | BACKGROUND: Ranolazine is a new anti-anginal agent that inhibits abnormal late sodium currents, indirectly causing a decrease in diastolic cardiomyocyte calcium levels. This produces an energy-sparing effect and stabilizes cardiac membranes. Ranolazine has been shown to be a potent inhibitor of triggered activity in the experimental setting.
METHODS: This case report describes the dramatic antiarrhythmic effects of ranolazine in a patient with highly symptomatic complex ventricular ectopy, including non-sustained ventricular tachycardia (NSVT). Cardiac ischemia and left ventricular systolic dysfunction were ruled out by cardiac catheterization. After failing standard treatment, we initiated ranolazine therapy.
RESULTS: Ranolazine was effective in suppressing ectopic ventricular activity and completely suppressed NSVT.
CONCLUSIONS: Further research on the anti-arrhythmic properties of ranolazine in the clinical setting is needed. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19886587 |
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