| Title | Synthesis of highly antibacterial nanocrystalline trivalent silver polydiguanide. | | Author(s) | Pal S, Yoon EJ, Tak YK, Choi EC, Song JM | | Institution | Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul, 151-742, South Korea. | | Source | J Am Chem Soc 2009 Nov 11; 131(44):16147-55. | | Abstract | Highly monodispersed nanoparticles of a trivalent silver polydiguanide complex are synthesized by oxidation of the monovalent silver, followed by stabilization of the oxidized higher-valent metal through complexation with a polydiguanide ligand in a reverse microemulsion at room temperature. The synthesized nanoparticles have excellent photostability and displayed superior antibacterial activity toward Gram-positive and Gram-negative prokaryotes of clinical interest in vitro compared to silver sulfadiazine. These nanoparticles may serve as a new generation antibacterial metallopharmaceutical in wound care. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19886698 |
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