Marfella R, Barbieri M, Ruggiero R, Rizzo MR, Grella R, Mozzillo AL, Docimo L, Paolisso G
Bariatric surgery reduces oxidative stress by blunting 24-hours acute glucose fluctuations in type 2 diabetic obese patients. [JOURNAL ARTICLE]
Diabetes Care 2009 Nov 4.
Objective- We evaluated the efficacy of malabsorptive bariatric surgery on daily blood glucose fluctuations and oxidative stress in type 2 diabetic obese patients. Research-Design-and-Methods- 48-h continuous subcutaneous glucose monitoring (CSGM) were assessed in type 2 patients before and 1 month after biliopancreatic diversion (BPD) (n=36), or after diet-induced equivalent weight loss (n=20). The mean amplitude of glycemic excursions (MAGE) and oxidative stress (nitrotyrosine) were evaluated during CSGM. During a standardized meal, glucagon-like peptide-1 (GLP-1), glucagon, and insulin were measured. Results- Fasting and postprandial glucose decreased equally in surgical and diet groups. A marked increase in GLP-1 occurred during interprandial period in surgical patients toward diet group (P<0.01). Glucagon was more suppressed during interprandial period in surgical patients compared to diet group (P<0.01). MAGE and nitrotyrosine levels decreased more after GBP than after diet (P<0.01). Conclusions Oxidative stress reduction after BPD seem to be related to the regulation of glucose fluctuations resulting from intestinal bypass.
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