| Title | Short-Term Bone Loss in HIV-Infected Premenopausal Women. | | Author(s) | Yin MT, Lu D, Cremers S, Tien PC, Cohen MH, Shi Q, Shane E, Golub ET, Anastos K | | Institution | From the *Department of Medicine, Columbia University Medical Center, New York, NY; daggerData Solutions LLC, Bronx, NY; double daggerDepartment of Medicine, University of California at San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA; section signDepartment of Medicine, Stroger (formerly Cook County) Hospital and Rush University, Chicago, IL; parallelDepartment of Medicine, New York Medical College, Valhalla, NY; paragraph signDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; and #Department of Medicine, Montefiore Medical Center, Bronx, NY. | | Source | J Acquir Immune Defic Syndr 2009 Nov 3. | | Abstract | BACKGROUND:: Low bone mineral density (BMD) has been reported in HIV+ women, but less is known about the longitudinal evolution of BMD and fracture incidence.
METHODS:: In 100 HIV+ and 68 HIV- premenopausal women in the Women's Interagency HIV Study, BMD was measured by dual energy x-ray absorptiometry at the femoral neck (FN) and lumbar spine (LS) at index visit and after a median of 2.5 years.
RESULTS:: In HIV+ women, BMD at index visit was normal but 5% lower at the LS and FN than in HIV- women. Annual percent decrease in BMD did not differ between HIV+ and HIV- women at the LS (-0.8% +/- 0.2% vs -0.4% +/- 0.2%, P = 0.20) or FN (-0.8% +/- 0.3% vs -0.6% +/- 0.3%, P = 0.56) and remained similar after adjustment for age, weight, and BMD at index visit. Among HIV+ women, bone loss was associated with vitamin D deficiency and opiate use but not with use or class of antiretrovirals. Incidence of self-reported fracture was 0.74 per 100 person-years in HIV+ women and similar in HIV- women.
CONCLUSIONS:: In premenopausal HIV+ women, index BMD was lower than comparable HIV- women; however, rates of bone loss at the LS and FN were similar over 2.5 years of observation, irrespective of antiretroviral therapy. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19890216 |
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