| Title | Sustained neurobehavioral effects of exposure to SSRI antidepressants during development: molecular to clinical evidence. | | Author(s) | Oberlander TF, Gingrich JA, Ansorge MS | | Institution | Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada. toberlander@cw.bc.ca | | Source | Clin Pharmacol Ther 2009 Dec; 86(6):672-7. | | Abstract | Selective serotonin reuptake inhibitor (SSRI) antidepressants are frequently used in the management of antenatal maternal mood disturbances. SSRIs readily cross the placenta and increase central serotonergic tone in the fetus. Given serotonin's key neurodevelopmental role, such prenatal exposure raises concerns about its impact on child development. Preclinical studies report enduring molecular, physiological, and behavioral consequences of developmental SSRI exposure. In humans, sustained developmental outcomes remain largely unstudied, and distinguishing between the effects of prenatal SSRI exposure and the impact of maternal mental illness remains a key challenge. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
| | PubMed ID | 19890255 |
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