| Title | Unexpected detection of melanoma brain metastasis by PET with iodine-124 betaCIT. | | Author(s) | Cascini GL, Ciarmiello A, Labate A, Tamburrini S, Quattrone A | | Institution | Department of Nuclear Medicine, University of Catanzaro, Catanzaro, Italy. cascini@unicz.it | | Source | Clin Nucl Med 2009 Oct; 34(10):698-9. | | Abstract | To study the potential impact of iodine-124-beta-carbomethoxy-3beta(4-iodophenyl)tropane (I-124 betaCIT) in Parkinson disease, a I-124 betaCIT-PET scan was performed in 30-year-old man with suspected early Parkinson disease. The scan showed normal striatum uptake together with a focal spot in the left parietal cortex. The subsequent magnetic resonance imaging of the brain revealed a corresponding nodular lesion, presumably representing a metastasis. After clinical and diagnostic evaluation, a malignant metastatic melanoma was discovered. betaCIT is a cocaine derivative with a high affinity for dopamine and serotonin transporters mainly used to image the density of the dopamine reuptake transporter. In fact the role of I-123 betaCIT is typically represented by Parkinsonian syndromes of uncertain classification. The iodine-124 betaCIT uptake is a marker of dopamine transporters density, and the presence of focal uptake corresponding to a lesion on magnetic resonance images suggests a specific binding in this case of melanoma brain metastasis. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19893406 |
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