Begg DP, Sinclair AJ, Stahl LA, Garg ML, Jois M, Weisinger RS
Dietary Protein Level Interacts With omega-3 Polyunsaturated Fatty Acid Deficiency to Induce Hypertension. [JOURNAL ARTICLE]
Am J Hypertens 2009 Nov 5.
BackgroundDietary omega-3 fatty acid deficiency can lead to hypertension in later life; however, hypertension is affected by numerous other dietary factors. We examined the effect of altering the dietary protein level on blood pressure in animals deficient or sufficient in omega-3 fatty acids.MethodsFemale rats were placed on one of four experimental diets 1 week prior to mating. Diets were either deficient (10% safflower oil; DEF) or sufficient (7% safflower oil, 3% flaxseed oil; SUF) in omega-3 fatty acids and contained 20 or 30% casein (DEF20, SUF20, DEF30, SUF30). Offspring were maintained on the maternal diet for the duration of the experiment. At 12, 18, 24, and 30 weeks, blood pressure was assessed by tail cuff plethysmography.ResultsAt both 12 and 18 weeks of age, no differences in blood pressure were observed based on diet, however, by 24 weeks hypertension was evident in DEF30 animals; there were no blood pressure differences between the other groups. This hypertension in DEF30 group was increased at 30 weeks, with systolic, diastolic, and mean arterial pressure all elevated.ConclusionsThese results indicate that the hypertension previously attributed to omega-3 fatty acid deficiency is dependent on additional dietary factors, including protein content. Furthermore, this study is the first to plot the establishment of omega-3 fatty acid deficiency hypertension over time.American Journal of Hypertension 2009; doi:10.1038/ajh.2009.198.
More from this journal |
