Effect of oral azithromycin in the treatment of chlamydial conjunctivitis. Eye (London, England) [Eye (Lond)] Journal article | | Title | Effect of oral azithromycin in the treatment of chlamydial conjunctivitis. | | Author(s) | Chen YM, Hu FR, Hou YC | | Institution | [1] Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan [2] Department of Ophthalmology, E-Da Hospital, I- Shou University, Kaohsiung, Taiwan. | | Source | Eye (Lond) 2009 Nov 6. | | Abstract | PurposeTo assess the efficacy of oral azithromycin in the treatment of chlamydial conjunctivitis.MethodsWe performed a retrospective study in patients with clinically suspected chlamydial conjunctivitis who underwent conjunctival swab sampling for Chlamydia direct fluorescent antibody (DFA) tests between 1 January 2006 and 31 December 2006. Patients with positive DFA results were orally administered azithromycin once a week for 2 consecutive weeks. If DFA examinations still showed positive results after 4 weeks, additional azithromycin was orally administered once. The DFA tests were repeated 4 weeks later, and this was continued until the DFA tests showed negative results.ResultsAmong the 67 suspected patients, 45 (67.2%) showed positive results from the DFA tests, of whom 42 received treatment. After the first 2 weeks, only 27 patients returned to the clinic and completed the treatment. The test results of 19 (70.4%) patients became negative after the treatment with two weekly doses of oral azithromycin. Among the remaining eight patients, four (14.8%) needed an additional dose of oral azithromycin, and the other four (14.8%) required two additional doses. All 27 patients tolerated the treatment well, with an adverse event of mild gastritis in only one patient.ConclusionsTwo weekly doses of oral azithromycin were effective and well tolerated in the treatment of chlamydial conjunctivitis. However, more than one course of treatment was necessary in some patients.Eye advance online publication, 6 November 2009; doi:10.1038/eye.2009.264. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19893589 |
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