| Title | Intrastriatal Transplantation of GDNF-engineered BMSCs and its neuroprotection in Lactacystin-induced Parkinsonian Rat Model. | | Author(s) | Wu J, Yu W, Chen Y, Su Y, Ding Z, Ren H, Jiang Y, Wang J | | Institution | Department of Neurology, Huashan Hospital Affiliated to Fudan University, 12 Wulumuqi Middle Road, 200040, Shanghai, People's Republic of China. | | Source | Neurochem Res 2009 Nov 6. | | Abstract | The potential value of glial cell line-derived neurotrophic factor (GDNF) in treating Parkinson's disease (PD) remains controversial. In order to evaluate the therapeutic effect of GDNF-engineered bone marrow stromal cells (BMSCs) in parkinsonian rat model, GDNF-BMSCs and LacZ-BMSCs were transplanted into striatum and followed by Lactacystin lesioning at median forebrain bundles 1 week later. We observed that the intrastriatal transplantation of GDNF-BMSCs could significantly rescue the dopaminergic neurons from lactacystin-induced neurotoxicity with regard to behavioral recovery, tyrosine hydroxylase level in nigra and striatum, and striatal dopamine level. We interpret the outcomes that intrastriatal transplantation of GDNF-BMSCs might be beneficial in the treatment of PD. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19894114 |
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