| Title | A Parametric Study on the Immunomodulatory Effects of Electroacupuncture in DNP-KLH Immunized Mice. | | Author(s) | Kim SK, Lee Y, Cho H, Koo S, Choi SM, Shin MK, Hong MC, Min BI, Bae H | | Institution | Department of Physiology, College of Oriental Medicine, Kyung Hee University, #1 Hoegi-dong, Dongdaemoon-gu, Seoul 130-701, Korea. hbae@khu.ac.kr. | | Source | Evid Based Complement Alternat Med 2009 Nov 9. | | Abstract | This study was conducted to compare the effects of low frequency electroacupuncture (EA) and high frequency EA at acupoint ST36 on the production of IgE and Th1/Th2 cytokines in BALB/c mice that had been immunized with 2,4-dinitrophenylated keyhole limpet protein (DNP-KLH), as well as to investigate the difference in the immunomodulatory effects exerted by EA stimulations at acupoint ST36 and at a non-acupoint (tail). Female BALB/c mice were divided into seven groups: normal (no treatments), IM (immunization only), ST36-PA (IM + plain acupuncture at ST36), ST36-LEA [IM + low frequency (1 Hz) EA at ST36], ST36-HEA [IM + high frequency (120 Hz) EA at ST36], NA-LEA [IM + low frequency (1 Hz) EA at non-acupoint] and NA-HEA [IM + high frequency (120 Hz) EA at non-acupoint]. EA stimulation was performed daily for two weeks, and total IgE, DNP-KLH specific IgE, IL-4 and IFN-gamma levels were measured at the end of the experiment. The results of this study showed that the IgE and IL-4 levels were significantly suppressed in the ST36-LEA and ST36-HEA groups, but not in the NA-LEA and NA-HEA groups. However, there was little difference in the immunomodulatory effects observed in the ST36-LEA and ST36-HEA groups. Taken together, these results suggest that EA stimulation-induced immunomodulation is not frequency dependent, but that it is acupoint specific. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19900958 |
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