Novel Ambler Class A Carbapenem-Hydrolyzing {beta}-Lactamase, from a Pseudomonas fluorescens in the Seine River, Paris, France. Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] Journal article | | Title | Novel Ambler Class A Carbapenem-Hydrolyzing {beta}-Lactamase, from a Pseudomonas fluorescens in the Seine River, Paris, France. | | Author(s) | Girlich D, Poirel L, Nordmann P | | Institution | Service de Bactériologie-Virologie, INSERM U914 <<Emerging Resistance to Antibiotics>>, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris Sud, 94275 K.-Bicêtre, France. | | Source | Antimicrob Agents Chemother 2009 Nov 9. | | Abstract | A Pseudomonas fluorescens (PF-1) isolate resistant to carbapenems was recovered during an environmental survey performed from the Seine river (Paris). It expressed a novel Ambler class A carbapenemase, BIC-1, sharing 68 and 59% amino acid identity with beta-lactamases SFC-1 from Serratia fonticola and the plasmid-encoded KPC-2, respectively. beta-Lactamase BIC-1 hydrolyzed penicillins, carbapenems and cephalosporins except ceftazidime and monobactams. The blaBIC-1 gene was chromosomally-located and was also identified in two other P. fluorescens strains isolated in the Seine river three months later. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19901091 |
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