| Title | Bevacizumab plus capecitabine as a salvage therapy in advanced adrenocortical carcinoma. | | Author(s) | Wortmann S, Quinkler M, Ritter C, Kroiss M, Johanssen S, Hahner S, Allolio B, Fassnacht M | | Institution | S Wortmann, Dept. of Medicine I, University of Würzburg, University Hospital, Würzburg, Germany. | | Source | Eur J Endocrinol 2009 Nov 10. | | Abstract | Objective: No standard therapy for advanced adrenocortical carcinoma (ACC) is established by any randomized trial but a consensus conference 2003 recommended mitotane as monotherapy or combined with etoposide, doxorubicin and cisplatin or with streptozotocin as first-line systemic therapy. However, there is no evidence for any therapy beneficial in patients failing these therapies. Therefore, we evaluated the effects of the anti-VEGF antibody bevacizumab plus capecitabine as salvage therapy in ACC.
Methods: Patients registered with the German ACC registry with refractory ACC progressing after cytotoxic therapies were offered treatment with bevacizumab (5mg/kg body weight i.v. every 21 days) and oral capecitabine (950 mg/m2 twice daily for 14 days followed by 7 days of rest) in 2006 - 2008. Evaluation of tumor response was performed by imaging according RECIST criteria every 12 weeks.
Results: Ten patients have been treated with bevacizumab plus capecitabine. None of them has experienced any objective response or stable disease. Two patients had to stop therapy after few weeks due to hand-foot syndrome and three patients died on progressive disease within 12 weeks. Other adverse events were mild (grade I-II). Median survival after treatment initiation was 124 days.
Conclusions: Bevacizumab plus capecitabine has no activity in patients with very advanced ACC. Hence this regimen can not be recommended as a salvage therapy. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19903796 |
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