Drost RM, Jonkers J
Preclinical mouse models for BRCA1-associated breast cancer. [JOURNAL ARTICLE]
Br J Cancer 2009 Nov 17; 101(10):1651-1657.
A substantial part of all hereditary breast cancer cases is caused by BRCA1 germline mutations. In this review, we will discuss the insights into BRCA1 functions that we obtained from mouse models with conventional and conditional mutations in Brca1. The most advanced models closely resemble human BRCA1-related breast cancer and may therefore be useful for addressing clinically relevant questions.
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