| Title | Changes in the distribution of nerve fibers immunoreactive to calcitonin gene-related Peptide according to growth and aging in rat molar periodontal ligament. | | Author(s) | Jung H, Horiuchi M, Soma K | | Institution | a Graduate PhD Student, Orthodontic Science, Department of Orofacial Development and Function, Tokyo Medical and Dental University, Tokyo, Japan. | | Source | Angle Orthod 2010 Mar; 80(2):309-15. | | Abstract | ABSTRACT
Objective: To analyze the age-dependent changes in nerve fibers immunoreactive to calcitonin gene-related peptide (CGRP-ir) in the periodontal ligaments of rats. Materials and
Methods: Thirty male Wistar-ST rats were divided into growing groups (5, 9, and 15 weeks of age) and aging groups (6, 12, and 24 months of age) (n = 5 in each group). Eight serial sagittal sections, 5 microm thick, were cut parallel to the distobuccal root of the maxillary right first molar. These tissues were stained with a rabbit monoclonal antibody against CGRP. The observation area was divided into three parts (mesial, apical, and distal) and observed using a light microscope.
Results: CGRP-ir nerve fibers were primarily distributed in the apical periodontal ligament in the growing group, with significantly more fibers than in the aging group.
Conclusions: CGRP-ir nerve fibers in the periodontal ligament are dense during the growth period and decrease gradually with aging, indicating that CGRP may affect periodontal tissue with growth and aging. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19905856 |
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