Goh KP, Chew K, Koh A, Guan M, Wong YS, Sum CF
The relationship between ACE gene ID polymorphism and aerobic capacity in Asian rugby players. [Journal Article]
Singapore Med J 2009 Oct; 50(10):997-1003.
Introduction: The aim of this study was to analyse the association between the ACE ID polymorphism and aerobic capacity in a homogeneous cohort of national Asian rugby players.
Methods: 17 subjects recruited during active training had their maximal oxygen uptake (V02max) and ventilatory threshold (VT) measured during maximal exercise testing. ACE genotyping was performed for all players.
Results: The likelihood of having a V02max above the 80th percentile of a gender-specific reference range for a normal population was 14.3-fold greater among subjects with the II genotype as compared to the ID genotype (p-value is 0.030). Similarly, subjects with the II genotype were 29.4 times more likely to have a VT above the gender-specific median value compared to the ID genotype (p-value is 0.019). The results suggest that the I allele confers an advantage in aerobic capacity as measured by the V02max and VT.
Conclusion: It is likely that the same physiological mechanisms mediated by the ACE gene are responsible for aerobic capacity in both Asians and Caucasians.
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