| Title | Drospirenone and cardiovascular risk in lean and obese polycystic ovary syndrome patients: a pilot study. | | Author(s) | Mancini F, Cianciosi A, Persico N, Facchinetti F, Busacchi P, Battaglia C | | Institution | Department of Obstetrics and Gynecology, University of Bologna, Italy; Department of Obstetrics, Gynecology and Reproductive Medicine, Institut Universitary Dexeus, Barcelona, Spain. | | Source | Am J Obstet Gynecol 2009 Nov 13. | | Abstract | OBJECTIVE: We sought to verify if an oral contraceptive (OC) containing drospirenone affects the cardiovascular risk of patients with polycystic ovary syndrome (PCOS).
STUDY DESIGN: A total of 28 women with PCOS (16 lean [group A] and 12 overweight [group B]) were assessed at baseline and after 6 months therapy with an OC. Leptin, homocysteine, endothelin-1, and flow-mediated dilatation of brachial artery were measured.
RESULTS: The brachial artery diameter and the pulsatility index, after the reactive hyperemia, did not change in group A; it improved significantly in group B after 6 months of treatment. At baseline and after therapy the plasma levels of homocysteine and endothelin-1 did not differ among the groups. Leptin was significantly lower at baseline in group A compared to group B.
CONCLUSION: The OC containing drospirenone does not seem to affect the surrogate markers of cardiovascular risk in lean patients with PCOS. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19913778 |
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