Miller JF, Turner EM, Sherrill RG, Gudmundsson K, Spaltenstein A, Sethna P, Brown KW, Harvey R, Romines KR, Golden P
Substituted tetrahydro-beta-carbolines as potential agents for the treatment of human papillomavirus infection. [JOURNAL ARTICLE]
Bioorg Med Chem Lett 2009 Oct 30.
The identification and optimization of a series of substituted tetrahydro-beta-carbolines with potent activity against human papillomavirus is described. Structure-activity studies focused on the substitution pattern and chirality of the beta-carboline ring system are discussed. Optimization of these parameters led to compounds with antiviral activities in the low nanomolar range.
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