Synthesis and Biological Activity of Oxa-Lacticin A2, a Lantibiotic Analogue with Sulfur Replaced by Oxygen. Organic letters [Org Lett] Journal article | | Title | Synthesis and Biological Activity of Oxa-Lacticin A2, a Lantibiotic Analogue with Sulfur Replaced by Oxygen. | | Author(s) | Liu H, Pattabiraman VR, Vederas JC | | Institution | Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2. | | Source | Org Lett 2009 Nov 18. | | Abstract | An oxidatively stable analogue 3 of lacticin 3147 A2 (2), wherein the sulfur atoms are replaced with oxygens, was synthesized using solution phase peptide synthesis and sequential on-resin cyclizations. Biological evaluation suggests that oxa-lacticin A2 (3) retains independent antimicrobial activity against Gram-positive bacteria but lacks the synergistic activity with natural lacticin A1 that is characteristic of the native lacticin A2 peptide. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19921853 |
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