| Title | Cholinergic signal activated renin angiotensin system associated with cardiovascular changes in the ovine fetus. | | Author(s) | Geng C, Mao C, Wu L, Cheng Y, Liu R, Chen B, Chen L, Zhang L, Xu Z | | Institution | Perinatal Origin Diseases Research Institute, First Affiliated Hospital of Soochow University, Suzhou, China. | | Source | J Perinat Med 2010; 38(1):71-6. | | Abstract | Abstract
Aim: Cholinergic regulation is important in the control of cardiovascular and endocrine responses. The mechanisms behind cardiovascular responses induced by cholinergic activation are explored by studying hormonal systems, including renin-angiotensin and vasopressin (VP).
Results: In chronically prepared fetal sheep, intravenous infusion of the cholinergic agonist carbachol increased fetal systolic, diastolic, and mean arterial pressure accompanied with bradycardia at near-term. Although intravenous administration of carbachol had no effect on plasma VP concentrations, this agonist increased angiotensin I and angiotensin II levels in fetal plasma. Fetal blood values, including sodium, osmolality, nitric oxide, hemoglobin, and hematocrit were unchanged by intravenous carbachol.
Conclusion: Cholinergic activation by carbachol controls fetal blood pressure and heart rate in utero. An over-activated fetal renin-angiotensin-system (RAS) is associated with changes in vascular pressure following intravenous administration of carbachol, indicating that the cholinergic stimulation-mediated hormonal mechanism in the fetus might play a critical role in the regulation of cardiovascular homeostasis. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19921993 |
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