| Title | mTOR/S6K1 and MAPK/RSK Signaling Pathways Coordinately Regulate Estrogen Receptor alpha Serine 167 Phosphorylation. | | Author(s) | Yamnik RL, Holz MK | | Institution | Department of Biology, Stern College for Women of Yeshiva University, New York, NY 10016. | | Source | FEBS Lett 2009 Nov 16. | | Abstract | Resistance to anti-estrogen therapy is a major clinical concern in treatment of breast cancer. Estrogen-independent phosphorylation of ERalpha, specifically on Ser167, is one of the contributing causes to development of resistance, and a prognostic marker for the disease. Here, we dissect the signaling pathways responsible for Ser167 phosphorylation. We report that the mTOR/S6K1 and MAPK/RSK contribute non-overlapping inputs into ERalpha activation via Ser167 phosphorylation. This cooperation may be targeted in breast cancer treatment by a combination of mTOR and MAPK inhibitors. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19925796 |
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