Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania. Journal of psychopharmacology (Oxford, England) [J Psychopharmacol] Journal article | | Title | Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania. | | Author(s) | Valvassori SS, Elias G, de Souza B, Petronilho F, Dal-Pizzol F, Kapczinski F, Trzesniak C, Tumas V, Dursun S, Chagas MH, Hallak JE, Zuardi AW, Quevedo J, Crippa JA | | Institution | Laboratório de Neurociências, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brasil. | | Source | J Psychopharmacol 2011 Feb; 25(2):274-80. | | MeSH | Amphetamine
Animals
Antimanic Agents
Bipolar Disorder
Brain-Derived Neurotrophic Factor
Cannabidiol
Corpus Striatum
Disease Models, Animal
Dopamine Agents
Dose-Response Relationship, Drug
Drug Administration Schedule
Hippocampus
Hyperkinesis
Male
Motor Activity
Oxidative Stress
Prefrontal Cortex
Protein Carbonylation
Rats
Rats, Wistar
| | Abstract | Cannabidiol (CBD), a Cannabis sativa constituent, may present a pharmacological profile similar to mood stabilizing drugs, in addition to anti-oxidative and neuroprotective properties. The present study aims to directly investigate the effects of CBD in an animal model of mania induced by D-amphetamine (D-AMPH). In the first model (reversal treatment), rats received saline or D-AMPH (2 mg/kg) once daily intraperitoneal (i.p.) for 14 days, and from the 8th to the 14th day, they were treated with saline or CBD (15, 30 or 60 mg/kg) i.p. twice a day. In the second model (prevention treatment), rats were pretreated with saline or CBD (15, 30, or 60 mg/kg) regime i.p. twice a day, and from the 8th to the 14th day, they also received saline or D-AMPH i.p. once daily. In the hippocampus CBD (15 mg/kg) reversed the d-AMPH-induced damage and increased (30 mg/kg) brain-derived neurotrophic factor (BDNF) expression. In the second experiment, CBD (30 or 60 mg/kg) prevented the D-AMPH-induced formation of carbonyl group in the prefrontal cortex. In the hippocampus and striatum the D-AMPH-induced damage was prevented by CBD (15, 30 or 60 mg/kg). At both treatments CBD did not present any effect against d-AMPH-induced hyperactivity. In conclusion, we could not observe effects on locomotion, but CBD protect against d-AMPH-induced oxidative protein damage and increased BDNF levels in the reversal model and these effects vary depending on the brain regions evaluated and doses of CBD administered. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 19939866 |
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