| Title | Adolescent cannabis use increases risk for cocaine-induced paranoia. | | Author(s) | Kalayasiri R, Gelernter J, Farrer L, Weiss R, Brady K, Gueorguieva R, Kranzler HR, Malison RT | | Institution | Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. | | Source | Drug Alcohol Depend 2010 Mar 1; 107(2-3):196-201. | | MeSH | Adolescent
Adolescent Behavior
Age Factors
Age of Onset
Cannabis
Catechol O-Methyltransferase
Cocaine-Related Disorders
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Logistic Models
Male
Paranoid Disorders
Polymerase Chain Reaction
Prevalence
Psychiatric Status Rating Scales
Risk Factors
Severity of Illness Index
Siblings
United States
| | Abstract | Cannabis can produce and/or exacerbate psychotic symptoms in vulnerable individuals. Early exposure to cannabis, particularly in combination with genetic factors, increases the risk of a subsequent, primary, psychotic disorder. Because paranoia is a common feature of stimulant abuse and cocaine-dependent individuals frequently endorse a history of cannabis abuse, we examined whether early cannabis exposure, in conjunction with polymorphic variation in the catechol-O-methyl transferase gene (COMT Val158Met), influences the risk for cocaine-induced paranoia (CIP).Cannabis-use history was obtained in 1140 cocaine-dependent individuals from a family-based (affected sibling pair) study using the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA). Logistic regression and generalized estimating equations' analyses were used to examine the role of adolescent-onset cannabis use (< or =15 years of age) on CIP risk, both controlling for previously implicated CIP risk factors and familial relationships, and considering potential interactions with COMT Val158Met genotype.Cocaine-dependent individuals who endorsed CIP had significantly higher rates of adolescent-onset cannabis use than those without CIP (62.2% vs. 50.2%; chi(2)=15.2, df=1, p<0.0001), a finding that remained after controlling for sibling correlations and other risk factors. There were no effects of COMT genotype or genotype by early cannabis onset interactions. A modest (OR=1.4) and nearly significant (p=0.053) effect of CIP status in probands on CIP status in siblings was also noted.Adolescent-onset cannabis use increases the risk of CIP in cocaine-dependent individuals. COMT genotype and its interaction with early cannabis exposure did not emerge as significant predictors of CIP. In addition, trait vulnerability to CIP may also be familial in nature. | | Language | eng | | Pub Type(s) | Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
| | PubMed ID | 19944543 |
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