| Title | The influence of diuretics on the excretion and metabolism of doping agents: Part VI. Pseudoephedrine. |
| Author(s) | Delbeke FT, Debackere M |
| Institution | Laboratorium voor Farmacologie en Toxicologie der Huisdieren, Faculteit Diergeneeskunde, Rijksuniversiteit Gent, Belgium. |
| Source | Biopharm Drug Dispos 1991 Jan-Feb; 12(1):37-48. |
| MeSH | Acetazolamide
Bumetanide
Chromatography, Gas
Diuretics
Ephedrine
Fluorocarbons
Humans
Water
|
| Abstract | A capillary gas chromatographic method with nitrogen specific detection is presented for measuring pseudoephedrine and its major metabolite norpseudoephedrine in urine after derivatization with trifluoroacetic anhydride. After the oral intake of 49.2 mg pseudoephedrine (ACTIFED) the active substance is nearly quantitatively excreted in urine over a 48 hr period. From 1 to 7 percent is metabolized to norpseudoephedrine. The intake of acetazolamide results in a suppression of the pseudoephedrine concentration for at least 12 h. The diuretic effect after the intake of 1.51 mineral water could be compared with the effect obtained with 1 mg bumetanide and results in a decrease in pseudoephedrine concentration by a factor 4 for several hours. |
| Language | eng |
| Pub Type(s) | Clinical Trial
Controlled Clinical Trial
Journal Article
|
| PubMed ID | 2039811 |
