| Title | Assessment of a fixed-dosage combination of atenolol and chlorthalidone (Tenoretic) in hypertensive Nigerians. | | Author(s) | Salako LA, Falase AO, Aderounmu AF, Walker O | | Institution | Department of Pharmacology and Therapeutics, University of Ibadan College of Medicine, Nigeria. | | Source | Afr J Med Med Sci 1990 Mar; 19(1):57-61. | | MeSH | Adult
Aged
Antihypertensive Agents
Atenolol
Blood Pressure
Chlorthalidone
Double-Blind Method
Drug Combinations
Female
Heart Rate
Humans
Male
Middle Aged
Nigeria
Randomized Controlled Trials
| | Abstract | The antihypertensive effect of a fixed dosage combination of the cardioselective beta-adrenoceptor blocker, atenolol, and the oral thiazide-like diuretic, chlorthalidone (Tenoretic) was studied in 24 hypertensive Nigerians in a double-blind, cross-over comparison with three other treatments. These were atenolol alone, 100 mg daily, chlorthalidone alone, 25 mg daily, and atenolol (100 mg) plus chlorthalidone (25 mg) daily taken as separate formulations. Tenoretic was taken as a once-daily tablet containing 100 mg atenolol plus 25 mg chlorthalidone. The order of administration of the drugs was randomized. Each drug was taken for 4 weeks. The results showed that atenolol and chlorthalidone lowered blood pressure to the same extent. Combination of the two drugs whether taken separately or in fixed-dosage combination was better than either product singly. The drugs were well tolerated. | | Language | eng | | Pub Type(s) | Clinical Trial
Journal Article
Randomized Controlled Trial
| | PubMed ID | 2109522 |
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