| Title | Effects of diet on high-density lipoprotein cholesterol. | | Author(s) | Siri-Tarino PW | | Institution | Atherosclerosis Research, Children's Hospital Oakland Research Institute, 5700 Martin Luther King Junior Way, Oakland, CA 94609, USA. psiri@chori.org | | Source | Curr Atheroscler Rep 2011 Dec; 13(6):453-60. | | MeSH | Alcohol Drinking
Cholesterol, HDL
Coronary Disease
Diet
Diet, Carbohydrate-Restricted
Diet, Mediterranean
Diet, Reducing
Dietary Fats
Fatty Acids, Omega-3
Humans
Metabolic Syndrome X
Risk Factors
Weight Loss
| | Abstract | Multiple dietary factors have been shown to increase high-density lipoprotein cholesterol (HDL-C) concentrations, and HDL-C has been inversely associated with coronary heart disease (CHD) risk. Replacement of dietary carbohydrate with polyunsaturated, monounsaturated and saturated fat has been associated with progressively greater increases in HDL-C (7-12%) in addition to other lipid changes. Added sugars, but not high glycemic carbohydrates, have been associated with decreased HDL-C. Alcohol consumption has been associated with increased HDL-C (9.2%) independent of changes in other measured lipids. Modest effects on HDL-C (~4-5%) among other lipid and non-lipid CHD risk factors have also been observed with weight loss by dieting, omega-3 fatty acids, and a Mediterranean diet pattern. The CHD benefit of increasing HDL-C is unclear given the inconsistent evidence from HDL-raising pharmacologic trials. Furthermore, pleiotropic effects of diet preclude attribution of CHD benefit specifically to HDL-C. Investigation into functional or other properties of HDL may lend further insight. | | Language | eng | | Pub Type(s) | Journal Article
Review
| | PubMed ID | 21901431 |
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