| Title | Combination therapy with platinum and etoposide of brain metastases from breast carcinoma. | | Author(s) | Cocconi G, Lottici R, Bisagni G, Bacchi M, Tonato M, Passalacqua R, Boni C, Belsanti V, Bassi P | | Institution | Medical Oncology Department, University Hospital, Parma. | | Source | Cancer Invest 1990; 8(3-4):327-34. | | MeSH | Adult
Aged
Antineoplastic Combined Chemotherapy Protocols
Bone Neoplasms
Brain Neoplasms
Breast Neoplasms
Drug Evaluation
Etoposide
Female
Humans
Leukopenia
Liver Neoplasms
Lung Neoplasms
Male
Middle Aged
Platinum
Regression Analysis
Remission Induction
| | Abstract | Twenty-two consecutive patients with brain metastases from breast carcinoma were treated with a combination of platinum (100 mg/m2 day 1) and etoposide (100 mg/m2 days 4, 6, 8) every three weeks. Five (23%) achieved a complete response (CR) while 7 (32%) obtained a partial response (PR) for an overall response rate of 55%. The 95% confidence interval for combined CR and PR was 34-76%. Five patients received brain irradiation after reaching the maximum degree of objective remission by chemotherapy. Median duration of combined CR plus PR was 40 weeks (12+; 152). Median duration of survival was 58 weeks (2; 208+). Fifty-five percent of the patients were alive at one year. Our study demonstrates that this combination treatment is highly effective in the management of brain metastases from breast carcinoma. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 2207757 |
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