| Title | Comparison of a dimethicone/antacid (Asilone gel) with an alginate/antacid (Gaviscon liquid) in the management of reflux oesophagitis. |
| Author(s) | Smart HL, Atkinson M |
| Institution | Department of Medicine, University of Sheffield, Royal Hallamshire Hospital. |
| Source | J R Soc Med 1990 Sep; 83(9):554-6. |
| MeSH | Adult
Alginates
Aluminum Hydroxide
Antacids
Bicarbonates
Comparative Study
Double-Blind Method
Drug Combinations
Esophagitis, Peptic
Esophagus
Female
Humans
Magnesium Oxide
Male
Research Support, Non-U.S. Gov't
Silicic Acid
Simethicone
Sodium Bicarbonate
|
| Abstract | Fifty-three patients with symptomatic reflux oesophagitis were entered into a single centre randomized study comparing the effects of a dimethicone/antacid (Asilone Gel) and an alginate/antacid (Gaviscon liquid) on symptoms and endoscopic changes over an 8-week period. Both treatments significantly improved heartburn, acid regurgitation and flatulence. Dimethicone/antacid but not alginate/antacid, produced a significant improvement in oesophagitis, oesophageal ulceration and histological grade of inflammation over the 8-week treatment period so that 14 patients treated with dimethicone/antacid and 10 with alginate/antacid had normal endoscopic oesophageal appearances at the end of the study. The difference in improvement between the two patient groups did not reach significance however, except for dimethicone/antacid improving histological changes (P less than 0.05). These findings suggest that dimethicone/antacid and alginate/antacid are equally effective in treating symptomatic reflux oesophagitis although dimethicone/antacid may have an advantage in improving oesophageal histological appearances. |
| Language | eng |
| Pub Type(s) | Clinical Trial
Journal Article
Randomized Controlled Trial
|
| PubMed ID | 2213800 |
