| Title | Topical corticosteroid compounding: effects on physicochemical stability and skin penetration rate. | | Author(s) | Krochmal L, Wang JC, Patel B, Rodgers J | | Institution | Pharmaceutical Research and Development Division, Bristol-Myers Co., Buffalo, New York. | | Source | J Am Acad Dermatol 1989 Nov; 21(5 Pt 1):979-84. | | MeSH | Administration, Topical
Anti-Inflammatory Agents
Chemistry
Desoximetasone
Drug Compounding
Fluocinonide
Hydrocortisone
Skin Absorption
Triamcinolone Acetonide
| | Abstract | Compounding compatibility studies of four corticosteroid cream products and four commonly added chemicals are presented. Physical alteration, chemical stability, micropreservative challenge status, and in vitro skin penetration were evaluated at ambient conditions for 2 months. The study was designed to generate useful, previously unavailable information to aid dispensing pharmacists and dermatologists. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 2808834 |
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