| Title | Pain relief after arthroscopy: naproxen sodium compared to propoxyphene napsylate with acetaminophen. | | Author(s) | Drez D, Ritter M, Rosenberg TD | | Source | South Med J 1987 Apr; 80(4):440-3. | | MeSH | Acetaminophen
Adolescent
Adult
Arthroscopy
Clinical Trials
Double-Blind Method
Female
Humans
Male
Menisci, Tibial
Middle Aged
Naproxen
Pain
Pain, Postoperative
Propoxyphene
Random Allocation
| | Abstract | We compared naproxen sodium (550 mg) and propoxyphene napsylate with acetaminophen (PN/A, 100 mg with 650 mg) for pain relief after arthroscopy or arthroscopic meniscectomy. Fifty-two patients entered this multicenter, double-blind, randomized, parallel trial. In each drug group, pain intensity values dropped consistently throughout this six-hour study from mean baseline levels of approximately 55 on a scale of 0 to 100. Pain intensity values were lower at each hour in the naproxen sodium than in the PN/A group and significantly lower at hour 1 (P = .008). Pain intensity differences (PID, reflecting change from baseline) mirrored this trend: greater mean PIDs were seen in the naproxen sodium group at each hour, and this difference between drug groups was statistically significant at hour 1 (P = .017). One patient in the naproxen sodium group and seven patients using PN/A took a second dose within the six hours. Patients in each drug group reported five complaints. | | Language | eng | | Pub Type(s) | Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
| | PubMed ID | 2882607 |
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