Knadler MP, Bergstrom RF, Callaghan JT, Obermeyer BD, Rubin A
Absorption studies of the H2-blocker nizatidine. [Clinical Trial, Controlled Clinical Trial, Journal Article]
Clin Pharmacol Ther 1987 Nov; 42(5):514-20.
The absolute and relative bioavailability of nizatidine, an H2-blocker, was studied in healthy male volunteers. The absolute oral bioavailability, relative to that after intravenous administration, was 98% +/- 14%. The bioavailability of single and multiple oral doses of 150 mg nizatidine was unaffected by concurrent food ingestion; nizatidine may be administered either with or without food. The relative bioavailability of nizatidine was compared when given simultaneously with placebo or Gelusil, 30 minutes after propantheline, or 60 minutes before activated charcoal. Gelusil reduced the amount of nizatidine absorbed by about 10%, charcoal reduced it by about 30%, and propantheline did not affect it.
More from this journalRelated subjects (MeSH) |
