| Title | Absorption studies of the H2-blocker nizatidine. | | Author(s) | Knadler MP, Bergstrom RF, Callaghan JT, Obermeyer BD, Rubin A | | Institution | Lilly Research Laboratories, Lilly Laboratory for Clinical Research, Indianapolis, IN. | | Source | Clin Pharmacol Ther 1987 Nov; 42(5):514-20. | | MeSH | Absorption
Administration, Oral
Adult
Aluminum Hydroxide
Biological Availability
Charcoal
Comparative Study
Drug Combinations
Drug Interactions
Histamine H2 Antagonists
Humans
Infusions, Intravenous
Magnesium Hydroxide
Male
Middle Aged
Nizatidine
Propantheline
Random Allocation
Silicic Acid
Thiazoles
Time Factors
| | Abstract | The absolute and relative bioavailability of nizatidine, an H2-blocker, was studied in healthy male volunteers. The absolute oral bioavailability, relative to that after intravenous administration, was 98% +/- 14%. The bioavailability of single and multiple oral doses of 150 mg nizatidine was unaffected by concurrent food ingestion; nizatidine may be administered either with or without food. The relative bioavailability of nizatidine was compared when given simultaneously with placebo or Gelusil, 30 minutes after propantheline, or 60 minutes before activated charcoal. Gelusil reduced the amount of nizatidine absorbed by about 10%, charcoal reduced it by about 30%, and propantheline did not affect it. | | Language | eng | | Pub Type(s) | Clinical Trial
Controlled Clinical Trial
Journal Article
| | PubMed ID | 2890459 |
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