Anticardiolipin antibodies: their presence as a marker for lupus anticoagulant in pregnancy. The New Zealand medical journal. [N Z Med J] Journal article

Title	Anticardiolipin antibodies: their presence as a marker for lupus anticoagulant in pregnancy.
Author(s)	Pattison NS, McKay EJ, Liggins GC, Lubbe WF
Source	N Z Med J 1987 Feb 11; 100(817):61-4.
MeSH	Abortion, Habitual Antibodies Antigens, Surface Autoantibodies Blood Coagulation Factors Cardiolipins Enzyme-Linked Immunosorbent Assay Female Humans Lupus Coagulation Inhibitor Lupus Erythematosus, Systemic Pregnancy Pregnancy Complications Thromboplastin
Abstract	A solid phase ELISA was developed to investigate the association between anticardiolipin antibodies and lupus anticoagulant in pregnancy. Twenty-seven pregnant women with a history of recurrent fetal losses or systemic lupus erythematosus (SLE) were tested for the presence of lupus anticoagulant, anticardiolipin antibodies, antinuclear antibodies (ANA) and anti-single-stranded DNA antibodies. Nineteen women with a total of 49 previous unsuccessful pregnancies were found to have lupus anticoagulant and anticardiolipin antibodies. Three women who had suffered four fetal deaths from six pregnancies had anticardiolipin antibodies without lupus anticoagulant. Cardiolipin antibodies were not detected in the remaining five patients. This assay for measuring anticardiolipin antibodies appears to provide a simple and inexpensive method of identifying women at risk of fetal death from the adverse effects of lupus anticoagulant.
Language	eng
Pub Type(s)	Journal Article
PubMed ID	3103033

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