Dinaline: a new oral drug against leukemia? Preclinical studies in a relevant rat model for human acute myelocytic leukemia (BNML). Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K [Leukemia] Journal article | | Title | Dinaline: a new oral drug against leukemia? Preclinical studies in a relevant rat model for human acute myelocytic leukemia (BNML). | | Author(s) | Hagenbeek A, Weiershausen U, Martens AC | | Institution | Radiobiological Institute TNO, Rijswijk, The Netherlands. | | Source | Leukemia 1988 Apr; 2(4):226-30. | | MeSH | Administration, Oral
Animals
Antineoplastic Agents
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Hematopoietic Stem Cells
Humans
Leukemia, Myeloid, Acute
Male
Neoplastic Stem Cells
Phenylenediamines
Rats
Rats, Inbred BN
| | Abstract | The efficacy and toxicity of Dinaline (GOE 1734; PD 104 208; NSC 328786; 4-amino-N-(2'-aminophenyl)benzamide) was evaluated in the Brown Norway acute myelocytic leukemia, which is generally accepted as a relevant preclinical model for human acute myelocytic leukemia. Upon repeated daily oral administration at least an 8 log leukemic cell kill was achieved with only less than a 1 log kill for normal pluripotent hemopoietic stem cells. Daily split-dose treatment even proved to be more effective and resulted in 40-50% cures. However, toxicity was also more pronounced in particular in regard to the gastrointestinal tract. So far, the mode of action of Dinaline is unknown, but its striking therapeutic index warrants further clinical investigation. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 3163079 |
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