| Title | Blood and plasma concentrations of butalbital following single oral doses in man. | | Author(s) | Drost ML, Walter L | | Institution | Royal Canadian Mounted Police, Forensic Laboratory, Edmonton, Alberta. | | Source | J Anal Toxicol 1988 Nov-Dec; 12(6):322-4. | | MeSH | Administration, Oral
Adult
Barbiturates
Chromatography, High Pressure Liquid
Female
Humans
Male
Salicylic Acids
| | Abstract | Blood and plasma concentrations of butalbital (from Fiorinal) were determined in a small group of healthy volunteers after single oral doses of 100 mg of butalbital. Butalbital was quantitated by high-performance liquid chromatography with ultraviolet detection. Typical blood concentrations of butalbital peaked at 2.1 mg/L and declined to 1.5 mg/L at 24 h. The half-lives in blood were between 35 and 87.5 h with a mean of 61 h. Whole blood to plasma ratios were also determined. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 3244271 |
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