| Title | The bioavailability of Tamoplex (tamoxifen). Part 3. A steady-state study in breast cancer patients. | | Author(s) | Slee PH, De Vos D, Chapman D, Stevenson D | | Institution | Department of Clinical, Oncology, Sint Jozef Ziekenhuis, Gouda, the Netherlands. | | Source | Pharm Weekbl Sci 1988 Feb 19; 10(1):22-5. | | MeSH | Adult
Aged
Biological Availability
Breast Neoplasms
Dose-Response Relationship, Drug
Female
Humans
Middle Aged
Tamoxifen
| | Abstract | The bioavailability of two tamoxifen preparations (Tamoplex and Nolvadex) was compared in a multiple dose two-way cross-over design in twelve breast cancer patients. The formulations were found to be bioequivalent. Mean steady-state serum levels of tamoxifen and N-desmethyltamoxifen were 133 ng/ml and 242 ng/ml, respectively, at a single daily dose of three tablets of Tamoplex 10 mg and 128 ng/ml and 248 ng/ml, respectively, at a single daily dose of three tablets of Nolvadex 10 mg. While there was a large interpatient as well as intrapatient variability in steady-state levels of tamoxifen and N-desmethyltamoxifen, their ratio appeared to be constant in the individual patient. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 3353207 |
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