| Title | The prognostic significance of bridging hepatic necrosis in chronic type B hepatitis: a histopathologic study. | | Author(s) | Chen TJ, Liaw YF | | Institution | Department of Pathology, Gung Memorial Hospital, Taipei, Taiwan, Republic of China. | | Source | Liver 1988 Feb; 8(1):10-6. | | MeSH | Biopsy
Chronic Disease
Female
Follow-Up Studies
Hepatitis B
Humans
Liver
Liver Cirrhosis
Male
Necrosis
Prognosis
Research Support, Non-U.S. Gov't
| | Abstract | A histopathologic follow-up study was conducted in 207 consecutive patients to examine the prognostic significance of bridging hepatic necrosis (BHN) in chronic type B hepatitis. One hundred and eight patients showed BHN and the other 99 intralobular spotty necrosis (SN) on initial biopsy. A higher proportion of patients with BHN healed (45.4% vs 26.4%) or developed cirrhosis (18.3% vs 3%) than the patients with SN. In contrast, intralobular inflammation persisted or recurred more frequently in the SN than in the BHN group (40.4% vs 5.6%). These figures were statistically significant (P less than 0.001). Alternatively, 87% of the patients who developed cirrhosis had had BHN as their initial histologic presentations. The estimated relative risk of cirrhotic progression for the BHN group compared to the SN group was 4:1. We conclude that BHN is a paradoxical prognostic factor, either for healing, or cirrhotic progression. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 3367703 |
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