| Title | The influence of diuretics on the excretion and metabolism of doping agents. Part IV--Caffeine. |
| Author(s) | Delbeke FT, Debackere M |
| Institution | Laboratorium voor Farmacologie en Toxicologie der Huisdieren, Faculteit Diergeneeskunde, Rijksuniversiteti Gent, Belgium. |
| Source | Biopharm Drug Dispos 1988 Mar-Apr; 9(2):137-45. |
| MeSH | Acetazolamide
Caffeine
Doping in Sports
Furosemide
Humans
Naphthols
|
| Abstract | The urinary excretion of caffeine in humans was followed over a period of 36 h after the oral administration of ANIMINE, a formulation containing caffeine-alpha-naphthylacetate. The excretion of caffeine was not as markedly affected by the urinary pH as was found with stimulant amines. Excretion peaks were obtained 1-2 h after the ingestion and the total amount of unchanged caffeine excreted during 12 h varied from 0.57 to 1.51 per cent. The ingestion of the diuretics acetazolamide or furosemide 2 h after caffeine resulted in a urine-flow dependent and consequently increased caffeine excretion during 2-4 h post-diuretic. This increase paralleled the increase in urine volume resulting in no meaningful differences in caffeine concentration compared to normal conditions. |
| Language | eng |
| Pub Type(s) | Journal Article
|
| PubMed ID | 3370304 |
