| Title | Tests for treponemal antibody in CSF. | | Author(s) | Jaffe HW, Larsen SA, Peters M, Jove DF, Lopez B, Schroeter AL | | Source | Arch Intern Med 1978 Feb; 138(2):252-5. | | MeSH | Adult
Antibodies
Cerebrospinal Fluid
Comparative Study
Evaluation Studies
False Positive Reactions
Fluorescent Antibody Technique
Hemagglutination Tests
Humans
Neurosyphilis
Prospective Studies
Retrospective Studies
Syphilis Serodiagnosis
Syphilis, Latent
Treponema pallidum
| | Abstract | We studied the potential usefulness of CSF treponemal tests in the diagnosis of neurosyphillis. The CSF was tested with the microhemagglutination test for Treponema pallidum (CSF-MHA-TP test) and with the CSF-FTA test by using undiluted CSF and CSF diluted in saline and in sorbent. In a prospective evaluation, of 177 nonsyphilitics, none had reactive CSF-MHA-TP tests and only one had a reactive CSF-FTA test. However, five of 15 syphilitics with no other evidence of neurosyphilis had reactive CSF-FTA tests. The CSF-FTA test reactivity appeared most likely when the titer of the serum FTA test was high. In a retrospective evaluation of syphilitics with reactive CSF-FTA tests, similar patterns of reactivity occurred in patients with and without other evidence of neurosyphilis. Without other supporting clinical or laboratory data, the diagnostic value of a reactive CSF-FTA test is unknown. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 343742 |
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